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Losartan 50 mg oral tablet, with a total dose of 150 mg. These patients may also receive a maintenance daily dose of 20 mg. This regimen is preferable to the prescribed for patients in placebo group, which may result in the development of a dose-related increase in adverse events. The dosage of pyrimethamine depends on the degree of weight loss in the treated group. dose of pyrimethamine should be increased if the weight change is less than 5%. The daily dose of pyrimethamine in the oral formulation is 100 mg, Acyclovir generic drug and a dose of 100 mg is also indicated once-a-day in the intravenous formulation (see PRECAUTIONS: Injection, Dosage, Administration, and Monitoring). When administering pyrimethamine parenterally, the dose of 100 mg twice a day is recommended (see DOSAGE AND ADMINISTRATION: Peritoneal Administration), pyrimethamine is also indicated in a bolus (see PRECAUTIONS: Injection, Dosage and Administration). Patients will be randomly assigned in a 1:1 ratio to receive either the 20-mg dose of pyrimethamine (n=50), or the placebo 20-mg dose (n=50) (see CLINICAL PHARMACOLOGY: Studies). The primary outcome measures are Percentage of Change in Body Weight (WBIW), Maximum Daily Number of Treatments (DND), and Rate Change from Baseline in the Percentage of Change Body Weight (WBIW). The secondary outcome is to assess overall safety. Treatment with pyrimethamine does not require a change in diet. Patients in Phase III studies of pyrimethamine may receive a placebo. Dosing Recommendations for patients being treated with pyrimethamine Each patient will be randomized to either receive the 0.3 mg/kg once-a-day dose or the 0.5 mg/kg once-a-day dose of pyrimethamine (see CLINICAL PHARMACOLOGY: Studies). Doses will then be adjusted in the same proportion as between-group patients in the placebo group (see CLINICAL PHARMACOLOGY: Studies). A total of 40 mg per day pyrimethamine is currently recommended, of which 40 mg will be administered once per day. Because the exact dosage regimen will vary depending on the response of patients involved, dose may need to be adjusted up or down at the time of each visit (see DRUG INTERACTIONS). The 40 mg per day dose of pyrimethamine is not designed to substitute for treatment with clopidogrel in patients who have established risk factors for thrombosis (e.g., coronary artery disease, peripheral arterial)

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